• David Steuer

How sleep deprivation harms our memory

Updated: Mar 27, 2019



Researchers from the University of Pennsylvania and University of Groningen have discovered a piece in the puzzle of how sleep deprivation negatively affects memory.

A study in mice has, for the first time, shown that five hours of sleep deprivation leads to a loss of connectivity between neurons in the hippocampus, a region of the brain associated with learning and memory. The study is published in the journal eLife.

“It’s clear that sleep plays an important role in memory,” said first author Robbert Havekes, a former postdoctoral researcher in Penn’s Department of Biology and now an assistant professor at the Groningen Institute for Evolutionary Life Sciences.

“We know that taking naps helps us retain important memories. But how sleep deprivation impairs hippocampal function and memory is less obvious.”

It has been proposed that changes in the connectivity between synapses –- structures that allow neurons to pass signals to each other –- can affect memory.

To study this further, the researchers examined the impact of brief periods of sleep loss on the structure of dendrites, the branching extensions of nerve cells along which impulses are received from other synaptic cells, in the mouse brain.


They first used the Golgi silver-staining method, which allows visualization of brain tissue, to measure the length of dendrites and number of dendritic spines in the mouse hippocampus following five hours of sleep deprivation, a period of sleep loss that is known to impair memory consolidation.

Their analyses indicated that sleep deprivation significantly reduced the length and spine density of the dendrites belonging to the neurons in the CA1 region of the hippocampus.

The scientists then repeated the sleep-loss experiment but left the mice to sleep undisturbed for three hours afterwards.

This period was chosen based on the scientists’ previous work showing that three hours is sufficient to restore deficits caused by lack of sleep.

The effects of the five-hour sleep deprivation in the mice were reversed so that their dendritic structures were similar to those observed in the mice that had slept.

The researchers then investigated what was happening during sleep deprivation at the molecular level.

“We were curious about whether the structural changes in the hippocampus might be related to increased activity of the protein cofilin since this can cause shrinkage and loss of dendritic spines,” Havekes said.

“Our further studies revealed that the molecular mechanisms underlying the negative effects of sleep loss do in fact target the protein cofilin.”

“Blocking this protein in hippocampal neurons of sleep-deprived mice not only prevented the loss of neuronal connectivity but also made the memory processes resilient to sleep loss. The sleep-deprived mice learned as well as non-sleep deprived subjects.”

“Lack of sleep is a common problem in our 24/7 modern society,” said Ted Abel, Brush Family Professor of Biology at Penn and senior author of the study, “and it has severe consequences for health, overall well-being and brain function.

“Despite decades of research, the reasons why sleep loss negatively impacts brain function have remained unknown.”

“Our novel description of a pathway through which sleep deprivation impacts memory consolidation highlights the importance of the neuronal cell network’s ability to adapt to sleep loss.”

“What is perhaps most striking is that these neuronal connections are restored with several hours of recovery sleep. Thus, when subjects have a chance to catch up on much-needed sleep, they are rapidly remodeling their brain.”


#sleep #improvememory #memory #remember

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This content is strictly the opinion of Dr. David Steuer and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Steuer nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

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