• David Steuer

Scalp cooling can help some breast cancer patients retain hair

Updated: Mar 28, 2019



Scalp cooling can lessen some chemotherapy-induced hair loss — one of the most devastating hallmarks of cancer — in certain breast cancer patients, according to a new multicenter study from UC San Francisco, Weill Cornell Medicine and three other medical centers.

A majority of the study’s patients, all women with stage 1 or 2 breast cancer who underwent scalp cooling, retained more than half of their hair after completing chemotherapy, the investigators learned. The study, which tracks patients over five years, used standardized photographs to grade hair loss.

The study will be published Feb. 14 in JAMA, the Journal of the American Medical Association.

“Hair loss is almost universal among breast cancer patients receiving adjuvant chemotherapy and is one of the most distressing of adverse side effects,” said first author Hope S. Rugo, M.D., the corresponding author who led the study. Rugo is a UCSF professor of medicine specializing in breast cancer research and treatment, and director of the breast oncology and clinical trials education program at the UCSF Helen Diller Family Comprehensive Cancer Center.

“We found that scalp cooling during commonly used chemotherapy regimens was well tolerated and was associated with significantly less hair loss, as well as improvement in several quality-of-life indicators,” Rugo said. “While further research is needed, the data suggest that when scalp cooling is successful at decreasing hair loss, it could improve the treatment experience for women undergoing adjuvant chemotherapy for early-stage breast cancer.”

Slowing cell division in the hair follicle

Breast cancer is the most common cancer in women around the world, both in developed countries and less developed ones, according to the World Health Organization.

Scalp cooling has been used in more than 30 countries as a way to potentially prevent hair loss in patients receiving chemotherapy; in Europe it’s been used for several decades. Two types of cooling caps are typically used: frozen caps that need to be replaced every half hour, or cooling systems that continually circulate coolants into a cap during the entire chemotherapy session.

Scalp cooling is thought to reduce hair loss due to reduced delivery of chemotherapy to the scalp and hair follicle, Rugo said. The cold temperatures also are thought to slow the hair follicle cell division, making the cell less susceptible to the damaging effects of chemotherapy.

In the United States, scalp cooling has been limited because of factors including insufficient scientific data and concern about the theoretic risk of scalp metastases.

'Effective and practical' method for retaining hair

For the JAMA study, researchers investigated the effectiveness of one device: the DigniCap scalp cooling system manufactured by the Swedish public company Dignitana AB, which partly funded the research. In December 2015, based on preliminary results from the study, the U.S. Food and Drug Administration cleared the DigniCap for use in the U.S., the first and only cooling cap to date to receive such clearance.

Scalp cooling began 30 minutes prior to each chemotherapy cycle and involved a close fitting of the silicone cap on the patient’s head, followed by an insulating neoprene cap. The silicone cap was then gradually cooled. The DigniCap is set to cool at 3 degrees Celsius (37 degrees Fahrenheit) with a temperature variance of plus or minus 2 degrees.

Of 101 patients who underwent scalp cooling, 67 of them (66.3 percent) retained half or more of their hair, the authors wrote. In the parallel control group, all the patients lost their hair. Additionally, three of five quality-of-life measures were significantly better for the women who underwent scalp-cooling, including feeling more physically attractive.

“Enabling a woman to preserve her hair during chemotherapy is empowering,” said senior author Tessa Cigler, M.D., MPH, an assistant professor of clinical medicine in the Weill Cornell Breast Center at Weill Cornell Medicine. “Scalp cooling allows patients to protect their privacy and maintain their self-esteem and sense of well-being. This study provides long-awaited evidence for an effective and practical scalp cooling method.”

The mean age of the cold cap patients was 53 years. Some 77 percent of the patients were white, 9 percent were black and nearly 11 percent were Asian. The study was conducted between August 2013 and October 2014. The average duration of chemotherapy was 2.3 months.

Many of the patients reported mild headaches or scalp pain associated with the scalp cooling. Two patients discontinued scalp cooling due to feeling cold. There has been no evidence of scalp metastases in any patient after approximately 30 months of follow up. All patient follow up will continue for a total of five years.

The study was funded partially by the Lazlo Tauber Family Foundation (awarded to UCSF); the Anne Moore Breast Cancer Research Fund (awarded to Weill Cornell Medicine); and the Friedman Family Foundation (awarded to Mount Sinai Beth Israel). Dignitana AB supported the design and conduct of the study, including collection, management, analysis and interpretation of the data.

Study co-authors also included researchers from the Icahn School of Medicine at Mount Sinai, New York; Wake Forest Baptist Health Medical Center; and the Jonsson Comprehensive Cancer Center at UCLA. From UCSF, co-authors are Michelle E. Melisko, M.D., and Laura Esserman, M.D., MBA; from Weill Cornell Medicine, Anne Moore, M.D., was also a co-author. A complete list of authors can be found in the paper.


#scalpcooling #cancerrisk #breastcancer #cancer #livercancer #hairloss

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This content is strictly the opinion of Dr. David Steuer and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Steuer nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

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